A Randomized, National, Open-label, Multicenter, Phase III Trial Studying Induction Therapy With Bortezomib/Lenalidomide/Dexamethasone (VRD-GEM), Followed by High-dose Chemotherapy With Melphalan-200 (MEL-200) Versus Busulfan-melphalan (BUMEL), and Consolidation With VRD-GEM in Patients Under 65 Years Old With Newly-diagnosed, Symptomatic Multiple Myeloma
Latest Information Update: 22 Sep 2024
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At a glance
- Drugs Busulfan (Primary) ; Melphalan (Primary) ; Bortezomib; Dexamethasone; Lenalidomide
- Indications Multiple myeloma
- Focus Therapeutic Use
- Acronyms PETHEMA/GEM2012
- 12 Dec 2023 Results of an analysis assessing clinical impact of PRD and MRD dynamics in MM patients receiving intensive treatment from two clinical studies: GEM2012MENOS65 trial and GEM2014MAIN trial presented at the 65th American Society of Hematology Annual Meeting and Exposition
- 06 Jun 2022 Results (n=374) from multiple myeloma patients enrolled in the GEM2012MENOS65 and GEM2014MAIN trials published in the Journal of Clinical Oncology
- 14 Dec 2021 Results (n=164) assessing treatment response by immunofixation , next generation flow cytometry and mass spectrometry by deriving samples, presented at the 63rd American Society of Hematology Annual Meeting and Exposition