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A Multicenter, Randomized, Double-blind, Parallel Group Study to Assess the Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients Comparing Two Titration Regimens

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Trial Profile

A Multicenter, Randomized, Double-blind, Parallel Group Study to Assess the Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients Comparing Two Titration Regimens

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 07 Nov 2021

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At a glance

  • Drugs Sacubitril/valsartan (Primary)
  • Indications Heart failure
  • Focus Adverse reactions
  • Acronyms TITRATION
  • Sponsors Novartis; Novartis Pharmaceuticals

    • Most Recent Events

    • 30 Mar 2020 Results (n=15,038) of meta-analysis exploring angioedema in the 6 clinical trials (PARADIGM-HF, PIONEER, TITRATION, EVALUATE-HF & PARAGON-HF) and in real-world pharmacovigilance data, presented at the 2020 Annual Scientific Session of the American College of Cardiology and World Congress of Cardiology.
    • 22 Nov 2017 Results of post-hoc analysis assessing relationship between SBP and initiation and up-titration of sacubitril/valsartan published in the European Journal of Heart Failure
    • 12 May 2016 Results published in the European Journal of Heart Failure

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