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A Non-randomised, Open-label, Sequential, Multicentre, Two-part, Phase I Study to Assess the Effect of Rifampicin, a CYP Inducer, on the Pharmacokinetics of Olaparib Following Oral Dosing of a Tablet Formulation in Patients With Advanced Solid Tumours

Trial Profile

A Non-randomised, Open-label, Sequential, Multicentre, Two-part, Phase I Study to Assess the Effect of Rifampicin, a CYP Inducer, on the Pharmacokinetics of Olaparib Following Oral Dosing of a Tablet Formulation in Patients With Advanced Solid Tumours

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 19 Jan 2017

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At a glance

  • Drugs Olaparib (Primary) ; Rifampicin
  • Indications Solid tumours
  • Focus Pharmacokinetics
  • Sponsors AstraZeneca
  • Most Recent Events

    • 13 Jan 2017 Status changed from active, no longer recruiting to completed.
    • 10 Oct 2016 Results assessing effect of rifampicin on pharmacokinetics of olaparib (n=22) published in the Clinical Therapeutics.
    • 02 Jun 2015 Results assessing pharmacokinetics of olaparib in presence of rifampin presented at the 51st Annual Meeting of the American Society of Clinical Oncology.
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