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A randomised, double-blind, placebo-controlled, parallel-group trial to assess clinical efficacy and safety of danegaptide in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention

Trial Profile

A randomised, double-blind, placebo-controlled, parallel-group trial to assess clinical efficacy and safety of danegaptide in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 20 Apr 2023

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At a glance

  • Drugs Danegaptide (Primary)
  • Indications Myocardial infarction; Myocardial reperfusion injury
  • Focus Proof of concept; Therapeutic Use
  • Sponsors Zealand Pharma
  • Most Recent Events

    • 30 Mar 2023 Results assessing if scar core mass, border zone (BZ) mass, and BZ channels are risk markers for subsequent ventricular arrhythmia (VA) in ST-segment elevation myocardial infarction published in the Europace
    • 02 Mar 2016 According to a Zealand Pharma media release, the company announced top line results from this phase II Proof-of-Concept trial of danegaptide for the protection against cardiac reperfusion injuries in patients with an acute myocardial infarction.
    • 02 Mar 2016 Primary endpoint [Myocardial Salvage Index [ Time Frame: 3 months ] [ Designated as safety issue: No ] Myocardial Salvage Index as assessed by MRI and calculated as the difference between myocardial volume at risk and final infarct size in relation to myocardial volume at riskhas not been met. (Myocardial Salvage Index)] has not been met.
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