Either you have JavaScript disabled or your browser does not support Javascript . To work properly, this page requires JavaScript to be enabled.
How to enable JavaScript in your browser?

An Open-Label, Phase 2 Basket Study of Neratinib in Patients With Solid Tumors With Somatic Activating HER Mutations

X
Trial Profile

An Open-Label, Phase 2 Basket Study of Neratinib in Patients With Solid Tumors With Somatic Activating HER Mutations

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 04 Jul 2024

Price : $35 *
  • Adis is an information provider.
  • Final gross price and currency may vary according to local VAT and billing address.
  • Your purchase entitles you to full access to the information contained in our trial profile at the time of purchase.
  • A link to download a PDF version of the trial profile will be included in your email receipt.

At a glance

  • Drugs Neratinib (Primary) ; Fulvestrant; Paclitaxel; Trastuzumab
  • Indications Adenocarcinoma; Advanced breast cancer; Biliary cancer; Bladder cancer; Carcinoma; Cervical cancer; Cholangiocarcinoma; CNS cancer; Colon cancer; Colorectal cancer; Endometrial cancer; Gallbladder cancer; Gastric cancer; Glioblastoma; Glioma; Gliosarcoma; HER2 negative breast cancer; HER2 positive breast cancer; Liver cancer; Lung cancer; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Periampullary cancer; Salivary gland cancer; Solid tumours; Squamous cell cancer; Triple negative breast cancer; Uterine cancer
  • Focus Therapeutic Use
  • Acronyms SUMMIT
  • Sponsors Puma Biotechnology
  • Most Recent Events

    • 04 Jun 2024 Results (n=27) assessing safety and efficacy of neratinib alone or in combination with trastuzumab in triple-negative breast cancer presented at the 60th Annual Meeting of the American Society of Clinical Oncology
    • 12 Mar 2024 Status changed from completed to discontinued.
    • 12 Feb 2024 This protocol has been amended as above-1) Number of treatment arms has been changed from 4 to 6. 2) Primary endpoints has been amended.3) Status of the trial has been changed from completed to terminated.

You need to be a logged in or subscribed to view this content Request demo

If your organization or you do not have a subscription, try one of the following:
  • Contacting your organization’s admin about adding this content to your AdisInsight subscription
  • Buying a PDF version of any individual profile
  • Request a free trial
If your organization has a subscription, there are several access options, even while working remotely:
  • Working within your organization’s network
  • with username/password or try to via your institution
  • Persisted access using your organization’s identifier stored in your user browser for 90 days
Back to top