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A Phase 2b, Dose-Ranging, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating the Safety and Efficacy of GS-6624, a Monoclonal Antibody Against Lysyl Oxidase-Like 2 (LOXL2), in Subjects With Compensated Cirrhosis Secondary to Non-Alcoholic Steatohepatitis (NASH)

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Trial Profile

A Phase 2b, Dose-Ranging, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating the Safety and Efficacy of GS-6624, a Monoclonal Antibody Against Lysyl Oxidase-Like 2 (LOXL2), in Subjects With Compensated Cirrhosis Secondary to Non-Alcoholic Steatohepatitis (NASH)

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 22 Dec 2021

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At a glance

  • Drugs Simtuzumab (Primary)
  • Indications Hepatic fibrosis; Liver cirrhosis; Non-alcoholic steatohepatitis
  • Focus Therapeutic Use
  • Sponsors Gilead Sciences

    • Most Recent Events

    • 18 Dec 2021 This trial has been completed in Italy global end of the trial is 2017-01-03 , according to European Clinical Trials Database record.
    • 18 Oct 2021 Results of a pooled analysis (NCT01672879 and NCT03053063 studies) assessing the associations between histologic and noninvasive tests of fibrosis (NITs) with liver-related complications in patients with NASH cirrhosis published in the Hepatology
    • 08 Dec 2020 Results of an analysis (n=2154) assessing associations between histologic and non-invasive fibrosis tests with clinical and patient-reported outcomes from four clinical studies: NCT01672866, NCT01672879, NCT03053050 and NCT03053063 published in the Gastroenterology
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