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A Randomized Double-blind, Placebo-controlled Study of LEE011 in Combination With Letrozole for the Treatment of Postmenopausal Women With Hormone Receptor Positive, HER2 Negative, Advanced Breast Cancer Who Received no Prior Therapy for Advanced Disease

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Trial Profile

A Randomized Double-blind, Placebo-controlled Study of LEE011 in Combination With Letrozole for the Treatment of Postmenopausal Women With Hormone Receptor Positive, HER2 Negative, Advanced Breast Cancer Who Received no Prior Therapy for Advanced Disease

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 30 Nov 2019

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At a glance

  • Drugs Ribociclib (Primary) ; Letrozole
  • Indications Advanced breast cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms MONALEESA-2
  • Sponsors Novare Pharmaceuticals; Novartis

    • Most Recent Events

    • 06 Nov 2019 Results evaluating the cost-effectiveness of ribociclib compared to palbociclib, both in combination with letrozole, in first-line treatment of postmenopausal women with advanced breast cancer presented at the 22nd Annual European Congress of the International Society for Pharmacoeconomics and Outcomes Research
    • 30 Oct 2019 Results assessing efficacy of Ribociclib in breast cancer patients from three studies (MONALEESA-2, -3, and -7), presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 2019.
    • 04 Jun 2019 Results presented at the 55th Annual Meeting of the American Society of Clinical Oncology
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