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A Randomized Double-blind, Placebo-controlled Study of LEE011 in Combination With Letrozole for the Treatment of Postmenopausal Women With Hormone Receptor Positive, HER2 Negative, Advanced Breast Cancer Who Received no Prior Therapy for Advanced Disease
A Randomized Double-blind, Placebo-controlled Study of LEE011 in Combination With Letrozole for the Treatment of Postmenopausal Women With Hormone Receptor Positive, HER2 Negative, Advanced Breast Cancer Who Received no Prior Therapy for Advanced Disease
Status:Discontinued
Phase of Trial:
Phase III
Latest Information Update:31 May 2020
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31 May 2020
Results (n=1503) of pooled ctDNA analysis from three MONALEESA trials: ML-2, ML-3 and ML-7 assessing potential biomarkers of response or resistance to ribociclib presented at the 56th Annual Meeting of the American Society of Clinical Oncology
27 May 2020
According to an Novartis media release, pooled analysis data from the MONALEESA trials will be presented during the ASCO20 Virtual Scientific Program
14 Dec 2019
Results assessing the potential for drug-drug interactions (DDIs) by comparing steady-state exposures data from study X2101 (NCT01237236) for Ribociclib alone with those of Ribociclib when used in combination with endocrine therapy in hormone receptor-positive, advanced breast cancer patients from four studies (NCT01872260,NCT01958021,NCT02278120 and NCT02422615), were presented at the 42nd Annual San Antonio Breast Cancer Symposium.
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