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A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Investigate the Safety and Efficacy of ABT-494 Given With Methotrexate (MTX) in Subjects With Moderately to Severely Active Rheumatoid Arthritis (RA) Who Have Had an Inadequate Response or Intolerance to Anti-TNF Biologic Therapy

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A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Investigate the Safety and Efficacy of ABT-494 Given With Methotrexate (MTX) in Subjects With Moderately to Severely Active Rheumatoid Arthritis (RA) Who Have Had an Inadequate Response or Intolerance to Anti-TNF Biologic Therapy

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 07 Nov 2021

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At a glance

  • Drugs Upadacitinib (Primary)
  • Indications Rheumatoid arthritis
  • Focus Therapeutic Use
  • Acronyms BALANCE-I
  • Sponsors AbbVie

    • Most Recent Events

    • 14 Oct 2019 Results of exposure response analysis of upadacitinib using data from Phase 2 and Phase 3 rheumatoid arthritis (RA) studies published in the Clinical Pharmacology and Therapeutics
    • 13 Jun 2019 Results of exposue response analysis of Upadacitinib efficacy in phase 2 trials (BALANCE-I and BALANCE-II) published in the Clinical Pharmacology and Therapeutics
    • 18 May 2019 This trial has been Discontinued in Netherlands , according to European Clinical Trials Database.

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