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Randomized, Double-blind, Placebo-controlled, Multi-centre, Multi-national Study to Evaluate the Efficacy and Safety of Oral BAY63-2521 (1 mg, 1.5 mg, 2 mg, or 2.5 mg Tid) in Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

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Trial Profile

Randomized, Double-blind, Placebo-controlled, Multi-centre, Multi-national Study to Evaluate the Efficacy and Safety of Oral BAY63-2521 (1 mg, 1.5 mg, 2 mg, or 2.5 mg Tid) in Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 24 Nov 2023

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At a glance

  • Drugs Riociguat (Primary)
  • Indications Pulmonary hypertension
  • Focus Registrational; Therapeutic Use
  • Acronyms CHEST-1
  • Sponsors Bayer; Bayer HealthCare

    • Most Recent Events

    • 01 Mar 2022 Results of post hoc analysis from CHEST-1 and CHEST-2, published in the Respiratory Medicine
    • 10 Jul 2021 Results (n=579) of post hoc analysis of hemodynamic data from PATENT-1 and CHEST-1 assessed whether riociguat improved right ventricular (RV) function parameters including stroke volume index (SVI), stroke volume, RV work index, and cardiac efficiency published in the Journal of Heart and Lung Transplantation
    • 19 Jul 2019 This trial has been completed in United Kingdom, according to European Clinical Trials Database

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