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A Phase 1 Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Escalating Oral Doses of the Glutaminase Inhibitor CB-839 in Patients With Advanced and/or Treatment-Refractory Hematological Malignancies

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Trial Profile

A Phase 1 Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Escalating Oral Doses of the Glutaminase Inhibitor CB-839 in Patients With Advanced and/or Treatment-Refractory Hematological Malignancies

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 24 Jul 2018

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At a glance

  • Drugs Telaglenastat (Primary)
  • Indications Diffuse large B cell lymphoma; Multiple myeloma; Non-Hodgkin's lymphoma; Waldenstrom's macroglobulinaemia
  • Focus Adverse reactions
  • Sponsors Calithera Biosciences

Most Recent Events

  • 29 Apr 2016 Status changed from recruiting to completed.
  • 27 Jan 2016 Number of treatment arms changed from 1 to 3 as reported by ClinicalTrials.gov record.
  • 27 Jan 2016 Planned number of patients changed from 65 to 25 as reported by ClinicalTrials.gov record.

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