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A Phase I Trial of p28 (NSC745104), a Non-HDM2 Mediated Peptide Inhibitor of p53 Ubiquitination in Pediatric Patients With Recurrent or Progressive CNS Tumors

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A Phase I Trial of p28 (NSC745104), a Non-HDM2 Mediated Peptide Inhibitor of p53 Ubiquitination in Pediatric Patients With Recurrent or Progressive CNS Tumors

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 03 Oct 2021

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At a glance

  • Drugs P28 peptide (Primary)
  • Indications Astrocytoma; CNS cancer; Diffuse intrinsic pontine glioma; Glioblastoma; Glioma; Gliosarcoma; Medulloblastoma; Neuroectodermal tumours; Oligodendroglioma; Rhabdoid tumour; Teratoma
  • Focus Adverse reactions; Pharmacogenomic

    • Most Recent Events

    • 21 Oct 2016 Status changed from active, no longer recruiting to completed.
    • 02 Jun 2015 Interim results in 12 patients presented at the 51st Annual Meeting of the American Society of Clinical Oncology.
    • 27 Oct 2014 According to the ClinicalTrials.gov record, planned end date changed from 1 Aug 2015 to 1 Dec 2015.

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