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An Open-Label, Multicentre, Corollary Study of Pre-Operative Therapy With Dabrafenib and the Combination of Dabrafenib With Trametinib in Subjects With BRAF Mutation-Positive Metastatic Melanoma to the Brain

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Trial Profile

An Open-Label, Multicentre, Corollary Study of Pre-Operative Therapy With Dabrafenib and the Combination of Dabrafenib With Trametinib in Subjects With BRAF Mutation-Positive Metastatic Melanoma to the Brain

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 15 Dec 2022

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At a glance

  • Drugs Dabrafenib (Primary) ; Trametinib (Primary)
  • Indications Brain metastases; Malignant melanoma
  • Focus Pharmacokinetics
  • Sponsors GlaxoSmithKline; GSK
  • Most Recent Events

    • 07 Dec 2022 Results of post hoc analysis assessing baseline clinical features associated with the outcomes of patients enrolled in the COMBI-MB phase II study of dabrafenib and trametinib treatment in patients with V600 BRAF-mutant metastatic melanoma with melanoma brain metastases published in the Clinical Cancer Research
    • 23 Aug 2018 The status of the trial has been changed to discontinued.
    • 22 Sep 2016 Planned End Date changed from 1 Oct 2016 to 1 Dec 2018.

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