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An Open-Label, Three-Period, Fixed Sequence Study to Investigate the Effect of Multiple Oral Doses of Posaconazole, a Potent Cytochrome P450 3A Inhibitor, on the Single Dose Pharmacokinetics of RO5424802 in Healthy Subjects

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Trial Profile

An Open-Label, Three-Period, Fixed Sequence Study to Investigate the Effect of Multiple Oral Doses of Posaconazole, a Potent Cytochrome P450 3A Inhibitor, on the Single Dose Pharmacokinetics of RO5424802 in Healthy Subjects

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 07 Nov 2021

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At a glance

  • Drugs Alectinib (Primary) ; Posaconazole (Primary)
  • Indications Aspergillosis; Candidiasis; Chagas disease; Cryptococcosis; Leishmaniasis; Mycoses; Non-small cell lung cancer; Oropharyngeal candidiasis; Phaeohyphomycosis; Trypanosomiasis; Zygomycosis
  • Focus Pharmacokinetics
  • Sponsors Roche

    • Most Recent Events

    • 12 Mar 2016 Results from this trial and other two trial (270330, 237396) presented at the 117th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics
    • 14 Mar 2014 According to the ClinicalTrials.gov record, status changed from active, no longer recruiting to completed.
    • 10 Feb 2014 As per the ClinicalTrials.gov record, status changed from recruiting to active, no longer recruiting.

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