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A Multinational, Randomised, Double-Blind, Placebo-Controlled Trial to Evaluate the Effect of Ticagrelor Twice Daily on the Incidence of Cardiovascular Death, Myocardial Infarction or Stroke in Patients With Type 2 Diabetes Mellitus (THEMIS - Effect of Ticagrelor on Health Outcomes in Diabetes Mellitus Patients Intervention Study)

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Trial Profile

A Multinational, Randomised, Double-Blind, Placebo-Controlled Trial to Evaluate the Effect of Ticagrelor Twice Daily on the Incidence of Cardiovascular Death, Myocardial Infarction or Stroke in Patients With Type 2 Diabetes Mellitus (THEMIS - Effect of Ticagrelor on Health Outcomes in Diabetes Mellitus Patients Intervention Study)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 30 Oct 2024

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At a glance

  • Drugs Ticagrelor (Primary) ; Aspirin
  • Indications Cardiovascular disorders; Myocardial infarction; Stroke
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms THEMIS
  • Sponsors AstraZeneca; AstraZeneca AB; AstraZeneca India
  • Most Recent Events

    • 02 Sep 2024 Results (n=19202) the relationship between baseline BMI and major adverse cardiovascular (CV) events, and to determine if the effects of ticagrelor vs. placebo varied across the BMI spectrum, in patients with diabetes and stable CAD, presented at the ESC Congress 2024 - Annual Congress of the European Society of Cardiology
    • 06 Mar 2023 Results of post hoc analysis assessing the prevalence and prognostic impact of angina in the THEMIS trial, and whether if it modified the effect of ticagrelor on clinical events, presented at the 72nd Annual Scientific Session of the American College of Cardiology together with the World Heart Federation.
    • 26 Dec 2022 Results describing the proportion of patients eligible and reasons for ineligibility for THEMIS within a population of patients with diabetes and CAD, published in the International Journal of Cardiology

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