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A P1 Ascending Dose Trial of the Safety and Tolerability of Toca 511, a Retroviral Replicating Vector, Administered Intravenously Prior to, and Intracranially at the Time of, Subsequent Resection for Recurrent HGG and Followed by Treatment With Extended-Release 5-FC

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Trial Profile

A P1 Ascending Dose Trial of the Safety and Tolerability of Toca 511, a Retroviral Replicating Vector, Administered Intravenously Prior to, and Intracranially at the Time of, Subsequent Resection for Recurrent HGG and Followed by Treatment With Extended-Release 5-FC

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 03 Apr 2019

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At a glance

  • Drugs Vocimagene amiretrorepvec-flucytosine gene therapy (Primary) ; Vocimagene amiretrorepvec-flucytosine gene therapy (Primary) ; Flucytosine
  • Indications Glioblastoma; Glioma
  • Focus Adverse reactions
  • Sponsors Tocagen

    • Most Recent Events

    • 27 Mar 2019 According to a Tocagen media release, data will be presented at the American Association for Cancer Research (AACR) Annual Meeting 2019 and and the 2019 American Association of Neurological Surgeons (AANS) Annual Meeting.
    • 16 May 2018 Status changed from active, no longer recruiting to completed.
    • 07 Feb 2018 According to ClinicalTrials.gov, the recruitment status of this study is unknown because the information has not been verified recently (last verified Feb 2016)
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