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A Randomized, Multicenter, Double-Blind, Parallel, Placebo-Controlled Study of the Effects of Canagliflozin on Renal Endpoints in Adult Subjects With Type 2 Diabetes Mellitus

Trial Profile

A Randomized, Multicenter, Double-Blind, Parallel, Placebo-Controlled Study of the Effects of Canagliflozin on Renal Endpoints in Adult Subjects With Type 2 Diabetes Mellitus

Status: Completed
Phase of Trial: Phase IV

Latest Information Update: 10 Aug 2019

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At a glance

  • Drugs Canagliflozin (Primary)
  • Indications Cardiovascular disorders; Type 2 diabetes mellitus
  • Focus Registrational; Therapeutic Use
  • Acronyms CANVAS-R
  • Sponsors Janssen Research & Development
  • Most Recent Events

    • 10 Aug 2019 Results assessing the effects of canagliflozin compared with placebo on fracture risk in CANVAS compared with CANVAS-R and seek to understand the heterogeneity between the two (NCT01032629, NCT01989754) trials published in the Diabetologia
    • 18 Mar 2019 Results presented at the 68th Annual Scientific Session of the American College of Cardiology
    • 18 Mar 2019 Time matched evaluation of cardiovascular risk associated with drugs using 10 trials (EXAMINE, SAVOR TIMI 53, TECOS, ELIXA, LEADEER, SUSTAIN-6, EXSCEL, EMPA-REG OUTCOME, CANVAS Program and DECLARE-TIMI 58); results published in the Clinical Drug Investigation
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