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A Phase 2B, Randomized, Controlled, Multicenter, Open-Label Study of the Efficacy and Immune Response of GVAX Pancreas Vaccine (With Cyclophosphamide) and CRS 207 Compared to Chemotherapy or to CRS-207 Alone in Adults With Previously-Treated Metastatic Pancreatic Adenocarcinoma

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A Phase 2B, Randomized, Controlled, Multicenter, Open-Label Study of the Efficacy and Immune Response of GVAX Pancreas Vaccine (With Cyclophosphamide) and CRS 207 Compared to Chemotherapy or to CRS-207 Alone in Adults With Previously-Treated Metastatic Pancreatic Adenocarcinoma

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 14 Jan 2020

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At a glance

  • Drugs CRS 207 (Primary) ; Tumour cell vaccine-GVAX (Primary) ; Capecitabine; Cyclophosphamide; Erlotinib; Fluorouracil; Folinic acid; Gemcitabine; Irinotecan
  • Indications Adenocarcinoma; Pancreatic cancer
  • Focus Therapeutic Use
  • Acronyms ECLIPSE
  • Sponsors Aduro BioTech

    • Most Recent Events

    • 24 May 2019 Primary endpoint (median OS of Arm A to Arm C in the primary cohort (third-line+).) has not been met as per results published in the Clinical Cancer Research
    • 24 May 2019 Results published in the Clinical Cancer Research
    • 25 Jan 2017 Status changed from active, no longer recruiting to completed.

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