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A Randomized, Double-blind, Placebo-controlled Phase III Study of Secukinumab to Demonstrate the Efficacy at 16 Weeks and to Assess the Long-term Safety, Tolerability and Efficacy up to 3 Years in Subjects With Active Ankylosing Spondylitis

Trial Profile

A Randomized, Double-blind, Placebo-controlled Phase III Study of Secukinumab to Demonstrate the Efficacy at 16 Weeks and to Assess the Long-term Safety, Tolerability and Efficacy up to 3 Years in Subjects With Active Ankylosing Spondylitis

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 24 Oct 2019

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At a glance

  • Drugs Secukinumab (Primary) ; Secukinumab (Primary)
  • Indications Ankylosing spondylitis
  • Focus Registrational; Therapeutic Use
  • Acronyms MEASURE 3
  • Sponsors Novartis; Novartis Pharma A.G.; Novartis Pharmaceuticals
  • Most Recent Events

    • 24 Oct 2019 According to a Novartis media release, based on data from this study (MEASURE 3), the European Commission (EC) has approved a label update for the up-titration of Cosentyx (secukinumab) to 300 mg for patients with active ankylosing spondylitis (AS).
    • 15 Jun 2019 Results of post hoc analysis pooled data from 4 trials (Measure 1-4) presented at the 20th Annual Congress of the European League Against Rheumatism.
    • 15 Jun 2019 Results assessing immunogenicity over 52 weeks from FUTURE 1-3 studies and MEASURE 1-4 studies published in The Journal of Rheumatology
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