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BRF117277: A Phase II, Open-Label, Multicentre Study of Dabrafenib Plus Trametinib in Subjects With BRAF Mutation-Positive Melanoma That Has Metastasized to the Brain

Trial Profile

BRF117277: A Phase II, Open-Label, Multicentre Study of Dabrafenib Plus Trametinib in Subjects With BRAF Mutation-Positive Melanoma That Has Metastasized to the Brain

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 07 Nov 2021

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At a glance

  • Drugs Dabrafenib (Primary) ; Trametinib (Primary)
  • Indications Brain metastases; Malignant melanoma
  • Focus Therapeutic Use
  • Acronyms COMBI-MB
  • Sponsors GlaxoSmithKline; Novartis; Novartis Pharma A.G.
  • Most Recent Events

    • 12 Feb 2021 Results of a clinical validation study assessing Circulating tumour DNA in patients with advanced melanoma from trials COMBI-d and COMBI-MB published in the Lancet Oncology
    • 20 Feb 2018 Status changed from active, no longer recruiting to completed.
    • 05 Jan 2018 This trial has been completed in Spain
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