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A 52-week, Multicenter, Randomized, Double-blind Study of Subcutaneous Secukinumab to Demonstrate Efficacy as Assessed by Psoriasis Area and Severity Index at 16 Weeks of Treatment Compared to Ustekinumab and to Assess Long-term Safety, Tolerability and Efficacy in Subjects With Moderate to Severe Plaque Psoriasis (CLEAR)

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A 52-week, Multicenter, Randomized, Double-blind Study of Subcutaneous Secukinumab to Demonstrate Efficacy as Assessed by Psoriasis Area and Severity Index at 16 Weeks of Treatment Compared to Ustekinumab and to Assess Long-term Safety, Tolerability and Efficacy in Subjects With Moderate to Severe Plaque Psoriasis (CLEAR)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 09 Nov 2022

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At a glance

  • Drugs Secukinumab (Primary) ; Ustekinumab
  • Indications Plaque psoriasis
  • Focus Therapeutic Use
  • Acronyms CLEAR
  • Sponsors Novartis; Novartis Pharmaceuticals

    • Most Recent Events

    • 05 Nov 2022 Results of a pooled analysis from two clinical trials: CLEAR and CLARITY trials assessing level of response in lower limbs versus other body regions in patient with moderate to severe psoriasis published in the BioDrugs
    • 25 Apr 2021 Results of a pooled analysis from two clinical studies: CLEAR and CLARITY presented at the American Academy of Dermatology Virtual Meeting Experience 2021
    • 25 Apr 2021 Results (n=1778) of updated analysis from CLEAR and CLARITY Trials; assessing the incremental burden of comorbid psoriatic arthritis on the clinical efficacy and safety of secukinumab vs ustekinumab among patients with moderate to severe plaque psoriasis, presented at the American Academy of Dermatology Virtual Meeting Experience 2021

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