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A Phase 1b, Open Label, Dose Finding Study To Evaluate Safety, Pharmacokinetics And Pharmacodynamics Of Axitinib (Ag-013736) In Combination With Pembrolizumab (Mk-3475) In Patients With Advanced Renal Cell Cancer

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Trial Profile

A Phase 1b, Open Label, Dose Finding Study To Evaluate Safety, Pharmacokinetics And Pharmacodynamics Of Axitinib (Ag-013736) In Combination With Pembrolizumab (Mk-3475) In Patients With Advanced Renal Cell Cancer

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 12 May 2022

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At a glance

  • Drugs Axitinib (Primary) ; Pembrolizumab (Primary)
  • Indications Renal cell carcinoma
  • Focus Adverse reactions
  • Acronyms KEYNOTE-035
  • Sponsors Pfizer
  • Most Recent Events

    • 04 Jan 2021 Results (data cut-off date, 23rd July 2019)long-term efficacy and safety of the axitinib/pembrolizumab after 46-55 months from study initiation, published in the European Journal of Cancer
    • 18 Aug 2020 Results published in the Clinical Cancer Research.
    • 31 May 2020 Results assessing long-term efficacy and safety data of the combination AXI/pembro from the Phase 1 trial, with almost 5 years of follow-up, presented at the 56th Annual Meeting of the American Society of Clinical Oncology.

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