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An Exploratory Phase 2, Randomized, Double-blind, Placebo-controlled, Parallel Design Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of AZD1722 in CKD Patients With Type 2 Diabetes Mellitus and Albuminuria

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Trial Profile

An Exploratory Phase 2, Randomized, Double-blind, Placebo-controlled, Parallel Design Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of AZD1722 in CKD Patients With Type 2 Diabetes Mellitus and Albuminuria

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 07 Nov 2021

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At a glance

  • Drugs Tenapanor (Primary)
  • Indications Proteinuria; Renal failure
  • Focus Therapeutic Use
  • Sponsors Ardelyx

    • Most Recent Events

    • 30 Jul 2015 According to an AstraZeneca media release, development of tenapanor in chronic kidney disease patients with type-2 diabetes mellitus has been discontinued for safety and efficacy reasons.
    • 05 May 2015 Results published in Ardelyx media release.
    • 05 May 2015 Primary endpoint has not been met. (Changes in Urine Albumin to Creatinine Ratio (UACR) [ Time Frame: Baseline to Week 12 ] [ Designated as safety issue: No ]), as per Ardelyx media release.

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