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A Phase Ib/II, Open-Label Study Evaluating the Safety, Efficacy and Pharmacokinetics of GDC-0199 (ABT-199) in Combination With Rituximab (R) or Obinutuzumab (G) Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) in Patients With B-Cell Non-Hodgkin's Lymphoma (NHL) and DLBCL

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Trial Profile

A Phase Ib/II, Open-Label Study Evaluating the Safety, Efficacy and Pharmacokinetics of GDC-0199 (ABT-199) in Combination With Rituximab (R) or Obinutuzumab (G) Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) in Patients With B-Cell Non-Hodgkin's Lymphoma (NHL) and DLBCL

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 30 Mar 2022

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At a glance

  • Drugs Venetoclax (Primary) ; Cyclophosphamide; Doxorubicin; Obinutuzumab; Prednisone; Rituximab; Vincristine
  • Indications B-cell lymphoma; Diffuse large B cell lymphoma; Follicular lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms CAVALLI
  • Sponsors Roche

    • Most Recent Events

    • 03 Mar 2022 Samples from this and other study (GOYA (NCT01287741)) were used for utility of NMF used in conjunction with targeted sequencing platforms for identifying patients with different prognostic subsets, published in the BMC Cancer
    • 25 Nov 2021 Results of population pharmacokinetics and exposure-response analyses published in the Advances in Therapy
    • 04 Feb 2021 Protocol was amended to mandate use of G-CSF (primary prophylaxis): PEGylated: pegfilgrastim or nonpegylated: filgrastim ; including timing and duration for all cycles involving CHOP chemotherapy; as part of the schedule of assessments.

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