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Cytoreductive treatment of dabrafenib combined with trametinib to allow complete surgical resection in patients with BRAF mutated, prior unresectable stage III or IV melanoma

Trial Profile

Cytoreductive treatment of dabrafenib combined with trametinib to allow complete surgical resection in patients with BRAF mutated, prior unresectable stage III or IV melanoma

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 02 Jan 2025

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At a glance

  • Drugs Dabrafenib (Primary) ; Trametinib (Primary)
  • Indications Malignant melanoma
  • Focus Therapeutic Use
  • Acronyms REDUCTOR

Most Recent Events

  • 24 Oct 2023 Results assessing update of long-term relapse-free survival (RFS), progression-free survival (PFS) and overall survival (OS), presented at the 48th European Society for Medical Oncology Congress.
  • 01 Aug 2021 Primary endpoint (Complete resection rate) has been met as per results published in the Annals of Surgery
  • 01 Aug 2021 Results published in the Annals of Surgery

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