Trial Profile

DOSE FINDING STUDY OF PF-05212384 WITH PACLITAXEL AND CARBOPLATIN IN PATIENTS WITH ADVANCED SOLID TUMOR

Status: Completed

Phase of Trial: Phase I

Latest Information Update: 17 Sep 2021

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At a glance

Drugs Gedatolisib (Primary) ; Carboplatin; Paclitaxel
Indications Adenocarcinoma; Endometrial cancer; Lung cancer; Non-small cell lung cancer; Ovarian cancer; Small cell lung cancer
Focus Adverse reactions

15 Jul 2021 Following the first 9 patients treated with the above mentioned schedule, the study was amended, dose of Gedatolisib 110mg and 130 mg has added in the treatment.
15 Jul 2021 Results published in the Clinical Cancer Research
21 Sep 2020 According to results presented at the 45th European Society for Medical Oncology Congress, Carboplatin was initially administered at AUC5 on day 8 and Paclitaxel at 80 mg/m2 on day 8, 15 and 22 and after a protocol amendment on day 1 and day 1, 8 and 15 respectively, in 28d cycles.

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