Phase II, Open Label, Single-arm Study to Assess Safety and Efficacy of AZD9291 in Patients With Locally Advanced/Metastatic NSCLC Whose Disease Has Progressed With Previous EGFR TKI and Whose Tumours Are EGFR and T790M Mutation Positive

Trial Profile

Phase II, Open Label, Single-arm Study to Assess Safety and Efficacy of AZD9291 in Patients With Locally Advanced/Metastatic NSCLC Whose Disease Has Progressed With Previous EGFR TKI and Whose Tumours Are EGFR and T790M Mutation Positive

Completed
Phase of Trial: Phase II

Latest Information Update: 05 Feb 2018

At a glance

  • Drugs Osimertinib (Primary)
  • Indications Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms AURA2
  • Sponsors AstraZeneca
  • Most Recent Events

    • 08 Jan 2018 Planned End Date changed from 16 May 2018 to 30 May 2018.
    • 23 Dec 2017 Results presenting a pre-specified subgroup analysis of CNS response using pooled data from two Phase II studies AURA extension (NCT01802632) and AURA2 (NCT02094261) published in the Annals of Oncology
    • 18 Oct 2017 Results of this and other trials (NCT01802632, NCT02094261 and NCT01544179) presented at the 18th World Conference on Lung Cancer
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