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Phase III, Double-Blind, Placebo-Controlled, Multicenter Study of the Efficacy and Safety of Etrolizumab During Induction and Maintenance in Patients With Moderate to Severe Active Ulcerative Colitis Who Have Been Previously Exposed to TNF Inhibitors

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Trial Profile

Phase III, Double-Blind, Placebo-Controlled, Multicenter Study of the Efficacy and Safety of Etrolizumab During Induction and Maintenance in Patients With Moderate to Severe Active Ulcerative Colitis Who Have Been Previously Exposed to TNF Inhibitors

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 27 Dec 2021

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At a glance

  • Drugs Etrolizumab (Primary)
  • Indications Ulcerative colitis
  • Focus Registrational; Therapeutic Use
  • Acronyms HICKORY
  • Sponsors Roche

Most Recent Events

  • 23 May 2021 Results assessing post-etrolizumab treatment changes in inflammatory cells, activated fibroblasts and epithelial cell subsets in intestinal biopsies from patients enrolled in two clinical studies: LAUREL and HICKORY presented at the Digestive Disease Week 2021
  • 13 Oct 2020 Results presented at the 28th United European Gastroenterology Week
  • 10 Aug 2020 According to a Roche media release, further analyses of the data, including secondary endpoints, are ongoing and will be submitted for presentation at upcoming medical meetings.

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