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A Phase Ib/II Multicenter Open-label Study of BGB324 as a Single Agent and in Combination With Cytarabine or Decitabine in Patients With Acute Myeloid Leukemia or as a Single Agent in Patients With Myelodysplastic Syndrome

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A Phase Ib/II Multicenter Open-label Study of BGB324 as a Single Agent and in Combination With Cytarabine or Decitabine in Patients With Acute Myeloid Leukemia or as a Single Agent in Patients With Myelodysplastic Syndrome

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 23 Dec 2024

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At a glance

  • Drugs Bemcentinib (Primary) ; Cytarabine; Decitabine
  • Indications Acute myeloid leukaemia; Myelodysplastic syndromes
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors BerGenBio

    • Most Recent Events

    • 19 Dec 2024 Status changed from active, no longer recruiting to completed.
    • 12 Dec 2023 Results assessing the final efficacy and safety data, as well as pharmacokinetic/pharmacodynamic analysis from part A were presented at the 65th American Society of Hematology Annual Meeting and Exposition.
    • 12 Dec 2023 Results from sub study assessing potential role of TNF alpha and cytotoxic immune cells in the successful application of bemcentinib-LDAC., presented at the 65th American Society of Hematology Annual Meeting and Exposition

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