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The effects of sonidegib, when given in combination with rimfampicin and ketoconazole, on CYP3A4 biomarker levels in healthy volunteers.

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Trial Profile

The effects of sonidegib, when given in combination with rimfampicin and ketoconazole, on CYP3A4 biomarker levels in healthy volunteers.

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 17 Feb 2017

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At a glance

  • Drugs Sonidegib (Primary) ; Ketoconazole; Rifampicin
  • Indications Basal cell cancer; Chronic myeloid leukaemia; Haematological malignancies; Medulloblastoma; Multiple myeloma; Myelofibrosis; Pancreatic cancer; Solid tumours
  • Focus Pharmacodynamics; Pharmacokinetics
  • Sponsors Novartis Pharmaceuticals Corporation

    • Most Recent Events

    • 25 Jan 2017 Results (n=45) published in the Drug Metabolism and Disposition.
    • 18 Apr 2014 Results published in the 115th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics.
    • 18 Apr 2014 New trial record

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