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A Multicenter, Single Arm, Phase Ib/II Study to Evaluate Efficacy, Safety, and PK of MSC2156119J as Monotherapy in Subjects With MET+ Advanced Hepatocellular Carcinoma With Child Pugh Class A Liver Function Who Have Failed Sorafenib Treatment

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Trial Profile

A Multicenter, Single Arm, Phase Ib/II Study to Evaluate Efficacy, Safety, and PK of MSC2156119J as Monotherapy in Subjects With MET+ Advanced Hepatocellular Carcinoma With Child Pugh Class A Liver Function Who Have Failed Sorafenib Treatment

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 08 Aug 2022

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At a glance

  • Drugs Tepotinib (Primary)
  • Indications Carcinoma; Liver cancer
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Merck KGaA

    • Most Recent Events

    • 01 Jul 2022 Results of a pooled exposure-efficacy analyses included data from an ongoing phase 2 study (VISION) and 4 completed studies (NCT01014936, NCT01832506, NCT01988493, NCT02115373, NCT02864992) investigating 500 mg/day tepotinib in NSCLC harboring METex14 skipping alterations published in the Cancer Chemotherapy and Pharmacology
    • 06 Apr 2021 Results published in the British Journal of Cancer
    • 17 Jan 2021 Results from NCT01988493 and NCT02115373 assesing activity of tepotinib in hepatocellular carcinoma with high level MET amplification, presented at the 2021 Gastrointestinal Cancers Symposium
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