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A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination With Durvalumab Versus Nivolumab Monotherapy in Subjects With Select Advanced Malignancies

Trial Profile

A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination With Durvalumab Versus Nivolumab Monotherapy in Subjects With Select Advanced Malignancies

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 10 May 2022

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At a glance

  • Drugs AMP 514 (Primary) ; Durvalumab (Primary) ; Nivolumab
  • Indications Bladder cancer; Renal cell carcinoma; Solid tumours
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors AstraZeneca; MedImmune

Most Recent Events

  • 04 May 2022 Results (n=63) evaluating antitumor activity and safety of MEDI0680 plus durvalumab versus nivolumab monotherapy in immunotherapy naive patients with advanced clear cell renal cell carcinoma, published in the Clinical Cancer Research
  • 08 Nov 2020 This trial has been Discontinued in Netherlands, according to European Clinical Trials Database record.
  • 10 Apr 2020 Status changed from active, no longer recruiting to completed.

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