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A Randomized, Double-Blind, Phase 3 Study of the Janus Kinase (JAK) 1/2 Inhibitor, Ruxolitinib, or Placebo in Combination With Capecitabine in Subjects With Advanced or Metastatic Adenocarcinoma of the Pancreas Who Have Failed or Are Intolerant to First-Line Chemotherapy (The JANUS 1 Study)

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Trial Profile

A Randomized, Double-Blind, Phase 3 Study of the Janus Kinase (JAK) 1/2 Inhibitor, Ruxolitinib, or Placebo in Combination With Capecitabine in Subjects With Advanced or Metastatic Adenocarcinoma of the Pancreas Who Have Failed or Are Intolerant to First-Line Chemotherapy (The JANUS 1 Study)

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 06 Nov 2021

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At a glance

  • Drugs Ruxolitinib (Primary) ; Capecitabine
  • Indications Adenocarcinoma; Pancreatic cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms JANUS 1
  • Sponsors Incyte Corporation

Most Recent Events

  • 06 Mar 2018 Primary endpoint (Overall Survival (OS)) has not been met as per the results published in the Investigational New Drugs.
  • 06 Mar 2018 Results assessing safety and efficacy published in the Investigational New Drugs
  • 27 Jan 2017 This trial has been completed in Spain (end date: 12 Dec 2016).

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