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A Phase III, Randomised, Double-blind, Placebo-controlled, Multi-centre, International Study of MEDI4736 as Sequential Therapy in Patients With Locally Advanced, Unresectable Non-Small Cell Lung Cancer (Stage III) Who Have Not Progressed Following Definitive, Platinum-based, Concurrent Chemoradiation Therapy (PACIFIC)

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Trial Profile

A Phase III, Randomised, Double-blind, Placebo-controlled, Multi-centre, International Study of MEDI4736 as Sequential Therapy in Patients With Locally Advanced, Unresectable Non-Small Cell Lung Cancer (Stage III) Who Have Not Progressed Following Definitive, Platinum-based, Concurrent Chemoradiation Therapy (PACIFIC)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 02 Jan 2025

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At a glance

  • Drugs Durvalumab (Primary)
  • Indications Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms PACIFIC
  • Sponsors AstraZeneca; AstraZeneca AB; AstraZeneca KK

Most Recent Events

  • 21 Sep 2023 Status changed from active, no longer recruiting to completed.
  • 28 Jun 2023 Planned End Date changed from 30 Jun 2023 to 31 Jul 2023.
  • 23 Feb 2023 Results of post-hoc subgroup analysis (At data cut-off January 11, 2021) assessing the efficacy and safety analysis from a subgroup of patients with EGFRm non-small cell lung cancer from PACIFIC, published in the Journal of Thoracic Oncology.

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