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A Phase 3 Multicenter, Double-Blind, Randomized, Active Comparator-Controlled Clinical Trial to Evaluate the Safety and Efficacy of Doravirine (MK-1439) 100 mg Once Daily Versus Darunavir 800 mg Once Daily Plus Ritonavir 100 mg Once Daily, Each in Combination With TRUVADA or EPZICOM/KIVEXA, in Treatment-Naive HIV-1 Infected Subjects

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Trial Profile

A Phase 3 Multicenter, Double-Blind, Randomized, Active Comparator-Controlled Clinical Trial to Evaluate the Safety and Efficacy of Doravirine (MK-1439) 100 mg Once Daily Versus Darunavir 800 mg Once Daily Plus Ritonavir 100 mg Once Daily, Each in Combination With TRUVADA or EPZICOM/KIVEXA, in Treatment-Naive HIV-1 Infected Subjects

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 25 Mar 2024

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At a glance

  • Drugs Doravirine (Primary) ; Darunavir; Emtricitabine/tenofovir disoproxil fumarate; Lamivudine/abacavir; Ritonavir
  • Indications HIV-1 infections
  • Focus Registrational; Therapeutic Use
  • Acronyms DRIVE-FORWARD
  • Sponsors Merck & Co; Merck Sharp & Dohme Corp.

Most Recent Events

  • 30 Mar 2023 Status changed from active, no longer recruiting to completed.
  • 19 Dec 2022 This trial has been completed in Italy, according to European Clinical Trials Database record.
  • 26 Oct 2022 Results (of three phase 3 studies DRIVE-FORWARD, DRIVE- AHEAD and DRIVE-SHIFT) assessing Factors associated with weight loss or stable weight after continuing or switching to a doravirine-based regimen presented at the 16th International Congress on Drug Therapy and HIV Infection

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