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A Multi-arm, Phase Ib, Open-Label, Multicentre Study to Assess the Safety,Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of AZD9291 in Combination With Ascending Doses of Novel Therapeutics in Patients With EGFRm+ Advanced NSCLC Who Have Progressed Following Therapy With an EGFR TKI (TATTON)

Trial Profile

A Multi-arm, Phase Ib, Open-Label, Multicentre Study to Assess the Safety,Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of AZD9291 in Combination With Ascending Doses of Novel Therapeutics in Patients With EGFRm+ Advanced NSCLC Who Have Progressed Following Therapy With an EGFR TKI (TATTON)

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 07 Mar 2024

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At a glance

  • Drugs Durvalumab (Primary) ; Osimertinib (Primary) ; Savolitinib (Primary) ; Selumetinib (Primary)
  • Indications Adenocarcinoma; Non-small cell lung cancer; Solid tumours
  • Focus Adverse reactions; Proof of concept
  • Acronyms TATTON
  • Sponsors AstraZeneca
  • Most Recent Events

    • 01 Mar 2024 Planned End Date changed from 29 Dec 2023 to 31 Dec 2024.
    • 04 Jan 2023 Planned End Date changed from 30 Dec 2022 to 29 Dec 2023.
    • 23 Jun 2022 Results published in the Clinical Cancer Research
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