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A Phase 1/2a Dose Escalation Study of AST-OPC1 in Subjects With Subacute Cervical Spinal Cord Injury

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Trial Profile

A Phase 1/2a Dose Escalation Study of AST-OPC1 in Subjects With Subacute Cervical Spinal Cord Injury

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 15 Sep 2025

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At a glance

  • Drugs OPC 1 (Primary) ; Tacrolimus
  • Indications Spinal cord injuries
  • Focus Adverse reactions; Proof of concept
  • Acronyms SCi-STAR; SCiSTAR
  • Sponsors Asterias Biotherapeutics; Lineage Cell Therapeutics

Most Recent Events

  • 04 Aug 2025 According to an Lineage Cell Therapeutics media release, a publication focused on outlining the Magnetic Resonance Imaging (MRI) evidence from this dose-escalation trial of OPC1 in subacute cervical SCI is also forthcoming.
  • 11 Sep 2023 According to an Lineage Cell Therapeutics media release, data from this study will be present at the 2023 International Spinal Research Trust (ISRT) Network Meeting, being held September 14 to 16, 2023, at the Holiday Inn Regent's Park, London, UK.
  • 01 Dec 2022 Results assessing the safety of 3 escalating doses of oligodendrocyte progenitor cells (LCTOPC1) administered at a single time point between 21 and 42 days postinjury to participants with subacute cervical spinal cord injuries, published in the Journal of Neurosurgery - Spine.

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