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A Randomized, Double-blind, Placebo-controlled, Phase 2 Study to Assess the Immune Response Following Administration of Zoster Vaccine to Subjects With Rheumatoid Arthritis Receiving Tofacitinib (CP-690,550) Or Placebo With Background Methotrexate Treatment

Trial Profile

A Randomized, Double-blind, Placebo-controlled, Phase 2 Study to Assess the Immune Response Following Administration of Zoster Vaccine to Subjects With Rheumatoid Arthritis Receiving Tofacitinib (CP-690,550) Or Placebo With Background Methotrexate Treatment

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 14 Nov 2018

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At a glance

  • Drugs Tofacitinib (Primary) ; Varicella zoster virus vaccine
  • Indications Rheumatoid arthritis
  • Focus Pharmacodynamics
  • Sponsors Pfizer
  • Most Recent Events

    • 14 Nov 2018 Results assessing Short-, Mid-, and Long-term Effects of Tofacitinib on Lymphocytes in RA patients using data from NCT00853385, NCT01039688, NCT00147498, NCT00413660, NCT00550446, CT02147587 and NCT00413699 sub-studies), published in the Arthritis and Rheumatology
    • 31 Aug 2018 Biomarkers information updated
    • 08 Nov 2017 Results of pooled data from two trial (NCT02147587 and NCT00413699) assessing evaluate the long-term effectiveness of LZV in patients with RA, via the incidence of HZ after treatment with tofacitinib for up to 27 months, were presented at the 81st American College of Rheumatology and the 52nd Association of Rheumatology Health Professionals Annual Scientific Meeting.
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