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A Randomized, Double-blind, Placebo-controlled, Phase III, Multi-centre Study of Eltrombopag or Placebo in Combination With Azacitidine in Subjects With IPSS Intermediate-1, Intermediate 2 and High-risk Myelodysplastic Syndromes (MDS)

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Trial Profile

A Randomized, Double-blind, Placebo-controlled, Phase III, Multi-centre Study of Eltrombopag or Placebo in Combination With Azacitidine in Subjects With IPSS Intermediate-1, Intermediate 2 and High-risk Myelodysplastic Syndromes (MDS)

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 30 Jun 2023

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At a glance

  • Drugs Eltrombopag (Primary) ; Azacitidine; Azacitidine
  • Indications Thrombocytopenia
  • Focus Registrational; Therapeutic Use
  • Acronyms SUPPORT
  • Sponsors GlaxoSmithKline; GlaxoSmithKline Research & Development; GSK; Novartis

    • Most Recent Events

    • 30 May 2019 This trial has been discontinued in Norway, according to European Clinical Trials Database.
    • 10 Oct 2018 Based on planned interim analyses, an independent data monitoring committee recommended stopping the study prematurely as efficacy outcomes crossed the predefined futility threshold, and for safety reasons.
    • 10 Oct 2018 Results published in the Blood

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