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A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Sequential Cohort, Dose-Ranging Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of TPI 287 in Patients With Primary Four Repeat Tauopathies: Corticobasal Syndrome or Progressive Supranuclear Palsy

Trial Profile

A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Sequential Cohort, Dose-Ranging Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of TPI 287 in Patients With Primary Four Repeat Tauopathies: Corticobasal Syndrome or Progressive Supranuclear Palsy

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 11 Nov 2019

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At a glance

  • Drugs TPI 287 (Primary)
  • Indications Progressive supranuclear palsy
  • Focus Adverse reactions
  • Acronyms TPI-287-4RT
  • Most Recent Events

    • 11 Nov 2019 Results assessing the safety, tolerability, and pharmacodynamics of the microtubule stabilizer TPI-287 (abeotaxane) in Alzheimer disease published in the JAMA Neurology
    • 31 Aug 2018 Biomarkers information updated
    • 01 May 2018 Planned End Date changed from 1 Aug 2017 to 1 Mar 2019.
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