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OPuS-2: A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Two Dose Levels of BCX4161 for 12 Weeks as an Oral Prophylaxis Treatment for Attacks of Hereditary Angioedema.

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Trial Profile

OPuS-2: A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Two Dose Levels of BCX4161 for 12 Weeks as an Oral Prophylaxis Treatment for Attacks of Hereditary Angioedema.

Status: Completed
Phase of Trial: Phase II/III

Latest Information Update: 28 Jul 2020

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At a glance

  • Drugs Avoralstat (Primary)
  • Indications Hereditary angioedema
  • Focus Therapeutic Use
  • Acronyms OPuS-2
  • Sponsors BioCryst Pharmaceuticals

    • Most Recent Events

    • 24 Apr 2018 Results (n=110) assessing the safety and efficacy of an oral treatment, BCX4161, in preventing acute attacks in subjects with hereditary angioedema (HAE), were published in the Allergy.
    • 15 Feb 2016 Status changed from active, no longer recruiting to completed, as reported by ClinicalTrials.gov.
    • 08 Feb 2016 Results published in a BioCryst media release.

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