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Phase I Study to Evaluate Cellular Immunotherapy Using Memory-Enriched T Cells Lentivirally Transduced to Express a CD19-Specific, Hinge-Optimized, CD28-Costimulatory Chimeric Receptor and a Truncated EGFR Following Lymphodepleting Chemotherapy in Adult Patients With High-Risk CD19+ Acute Lymphoblastic Leukemia

Trial Profile

Phase I Study to Evaluate Cellular Immunotherapy Using Memory-Enriched T Cells Lentivirally Transduced to Express a CD19-Specific, Hinge-Optimized, CD28-Costimulatory Chimeric Receptor and a Truncated EGFR Following Lymphodepleting Chemotherapy in Adult Patients With High-Risk CD19+ Acute Lymphoblastic Leukemia

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 04 Dec 2023

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At a glance

  • Drugs Axicabtagene ciloleucel (Primary)
  • Indications Precursor B-cell lymphoblastic leukaemia-lymphoma
  • Focus Adverse reactions; Therapeutic Use
  • Most Recent Events

    • 28 Nov 2023 Planned End Date changed from 30 Sep 2023 to 24 Sep 2024.
    • 28 Nov 2023 Planned primary completion date changed from 30 Sep 2023 to 24 Sep 2024.
    • 13 Dec 2022 Status changed from active, no longer recruiting to completed as per results presented at the 64th American Society of Hematology Annual Meeting and Exposition
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