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A Multicenter Phase I Dose-finding and Preliminary Efficacy Study of the Histone Deacetylase Inhibitor Romidepsin (Istodax) in Combination With Gemcitabine (Gemzar), Oxaliplatin (Eloxatin), and Dexamethasone for the Treatment of Adults With Relapsed/Refractory Aggressive Lymphomas

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Trial Profile

A Multicenter Phase I Dose-finding and Preliminary Efficacy Study of the Histone Deacetylase Inhibitor Romidepsin (Istodax) in Combination With Gemcitabine (Gemzar), Oxaliplatin (Eloxatin), and Dexamethasone for the Treatment of Adults With Relapsed/Refractory Aggressive Lymphomas

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 20 Nov 2020

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At a glance

  • Drugs Romidepsin (Primary) ; Dexamethasone; Gemcitabine; Oxaliplatin; Pegfilgrastim
  • Indications Cutaneous T-cell lymphoma; Diffuse large B cell lymphoma; Hodgkin's disease; Mycosis fungoides; Peripheral T-cell lymphoma; Sezary syndrome; T-cell lymphoma
  • Focus Adverse reactions

    • Most Recent Events

    • 16 Nov 2020 Status changed from active, no longer recruiting to completed.
    • 06 Nov 2019 Results (n=24) released at the 61st Annual Meeting and Exposition of the American Society of Hematology.
    • 12 Mar 2019 Planned primary completion date changed from 30 Apr 2019 to 28 Mar 2019.

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