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Randomized Phase II Study of Induction Bevacizumab, Etoposide and Cisplatin Followed by Whole Brain Radiotherapy (WBRT) Versus WBRT Alone in Breast Cancer With Untreated Brain Metastases

Trial Profile

Randomized Phase II Study of Induction Bevacizumab, Etoposide and Cisplatin Followed by Whole Brain Radiotherapy (WBRT) Versus WBRT Alone in Breast Cancer With Untreated Brain Metastases

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 05 May 2023

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At a glance

  • Drugs Bevacizumab (Primary) ; Cisplatin; Etoposide; Granulocyte colony-stimulating factors
  • Indications Advanced breast cancer; Brain metastases
  • Focus Therapeutic Use
  • Acronyms A-PLUS

Most Recent Events

  • 06 May 2021 Planned End Date changed from 1 Jul 2020 to 1 Nov 2022.
  • 31 May 2020 Primary endpoint (The Brain-specific progression free survival (BS-PFS)) has been met.
  • 31 May 2020 Results presented at the 56th Annual Meeting of the American Society of Clinical Oncology

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