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A Phase IB, Open Label Study to Examine the Safety, Pharmacokinetic Characteristics and Anti-Inflammatory Effects of the NK-1R Antagonist, Aprepitant, In HIV-Infected Subjects Receiving Atazanavir/Ritonavir Or Darunavir/Ritonavir

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A Phase IB, Open Label Study to Examine the Safety, Pharmacokinetic Characteristics and Anti-Inflammatory Effects of the NK-1R Antagonist, Aprepitant, In HIV-Infected Subjects Receiving Atazanavir/Ritonavir Or Darunavir/Ritonavir

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 06 Nov 2021

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At a glance

  • Drugs Aprepitant (Primary)
  • Indications HIV-1 infections
  • Focus Adverse reactions; Biomarker; Pharmacodynamics; Pharmacokinetics
  • Acronyms Emend-IV

    • Most Recent Events

    • 11 Jun 2021 Results of pooled analysis of data from 3 phase Ib studies (NCT00428519, NCT01300988, and NCT02154360) assessing the effect of aprepitant on kynurenine to tryptophan ratio in cART treated and cART naive adults living with HIV published in the Medicine
    • 01 Jun 2016 Status changed from recruiting to completed.
    • 28 May 2015 Planned primary completion date changed from 1 Jun 2015 to 1 Aug 2015 according to ClinicalTrials.gov record.

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