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A Phase II Trial of SGI-110 in Patients With IPSS High and Int 2 Myelodysplastic Syndrome, Acute Myeloid Leukemia With 20-30% Marrow Blasts or Chronic Myelomonocytic Leukemia Type 2 Not Responding to Azacitidine or Decitabine After at Least 6 Courses or Relapsing After a Response

Trial Profile

A Phase II Trial of SGI-110 in Patients With IPSS High and Int 2 Myelodysplastic Syndrome, Acute Myeloid Leukemia With 20-30% Marrow Blasts or Chronic Myelomonocytic Leukemia Type 2 Not Responding to Azacitidine or Decitabine After at Least 6 Courses or Relapsing After a Response

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 16 Dec 2018

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At a glance

  • Drugs Guadecitabine (Primary)
  • Indications Acute myeloid leukaemia; Chronic myelomonocytic leukaemia; Myelodysplastic syndromes
  • Focus Therapeutic Use
  • Most Recent Events

    • 03 May 2018 Status changed from active, no longer recruiting to completed.
    • 09 Feb 2018 Planned End Date changed from 1 Feb 2018 to 1 Apr 2018.
    • 05 Apr 2017 Results from NCT02293993 and NCT02197676 studies evaluating integrated molecular profiles and guadecitabine response in relapsed/refractory acute myeloid leukemia, presented at the 108th Annual Meeting of the American Association for Cancer Research
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