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A Phase I, Open-Label, Non-Randomised, Multicentre Study to Assess the Effect of AZD9291 on the Pharmacokinetics of Simvastatin (a Sensitive CYP3A4 Substrate) in Patients With EGFRm Positive NSCLC Whose Disease Has Progressed on an EGFR TKI

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Trial Profile

A Phase I, Open-Label, Non-Randomised, Multicentre Study to Assess the Effect of AZD9291 on the Pharmacokinetics of Simvastatin (a Sensitive CYP3A4 Substrate) in Patients With EGFRm Positive NSCLC Whose Disease Has Progressed on an EGFR TKI

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 25 Sep 2024

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At a glance

  • Drugs Osimertinib (Primary) ; Simvastatin (Primary)
  • Indications Non-small cell lung cancer
  • Focus Pharmacokinetics
  • Sponsors AstraZeneca

Most Recent Events

  • 09 Sep 2024 Status changed from active, no longer recruiting to completed.
  • 09 Feb 2024 Planned End Date changed from 29 Nov 2023 to 31 Dec 2024.
  • 13 Jan 2023 Planned End Date changed from 30 Dec 2022 to 29 Nov 2023.

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