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A Phase Ib, Open-label, Multicenter, Dose Escalation and Expansion Study, to Evaluate the Safety, Pharmacokinetics and Activity of INC280 in Combination With Cetuximab in c-MET Positive CRC and HNSCC Patients Who Have Progressed After Anti-EGFR Monoclonal Antibody Therapy.

Trial Profile

A Phase Ib, Open-label, Multicenter, Dose Escalation and Expansion Study, to Evaluate the Safety, Pharmacokinetics and Activity of INC280 in Combination With Cetuximab in c-MET Positive CRC and HNSCC Patients Who Have Progressed After Anti-EGFR Monoclonal Antibody Therapy.

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 28 Jan 2019

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At a glance

  • Drugs Capmatinib (Primary) ; Cetuximab
  • Indications Colorectal cancer; Head and neck cancer; Squamous cell cancer
  • Focus Adverse reactions
  • Sponsors Novartis
  • Most Recent Events

    • 31 Aug 2018 Biomarkers information updated
    • 10 Dec 2017 This trial has been completed in Germany (end date:2017-01-20).
    • 21 Jul 2017 Status changed from suspended to discontinued.
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