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Pazopanib Neoadjuvant Trial in Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC737754)

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Trial Profile

Pazopanib Neoadjuvant Trial in Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC737754)

Status: Completed
Phase of Trial: Phase II/III

Latest Information Update: 19 Jun 2026

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At a glance

  • Drugs Pazopanib (Primary) ; Doxorubicin; Ifosfamide
  • Indications Alveolar soft part sarcoma; Cancer metastases; Carcinoma; Chondrosarcoma; Clear cell sarcoma; Fibroma; Haemangiosarcoma; Histiocytoma; Leiomyosarcoma; Liposarcoma; Liver cancer; Malignant fibrous histiocytoma; Muscle tissue neoplasms; Nerve sheath neoplasms; Osteosarcoma; Sarcoma; Soft tissue sarcoma; Synovial sarcoma
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms PAZNTIS

Most Recent Events

  • 16 Jun 2026 Status changed from active, no longer recruiting to completed.
  • 03 Mar 2026 Planned End Date changed from 22 Dec 2024 to 24 Dec 2026.
  • 31 Jul 2023 Results (As of December 31, 2021, n=85) assessing assessing Outcomes After Preoperative Chemoradiation With or Without Pazopanib in Non-Rhabdomyosarcoma Soft Tissue Sarcoma published in the Journal of Clinical Oncology

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