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Harmonizing Optimal Strategy for Treatment of Coronary Artery Diseases Trial - Comparison of REDUCTION of PrasugrEl Dose & POLYmer TECHnology in ACS Patients (HOST REDUCE POLYTECH RCT Trial) Comparison of the Efficacy and Safety of Biostable Polymer DES (Promus PremierTM, Xience Alpine®, and Resolute Onyx®) With Biodegradable Polymer DES (Biomatrix®, Biomatrix Flex®, Nobori®, Ultimaster®,Synergy®, and Orsiro®)and Conventional Dose Prasugrel Therapy With Reduced Dose Prasugrel Therapy in Acute Coronary Syndrome Patients Treated With Percutaneous Coronary Intervention

Trial Profile

Harmonizing Optimal Strategy for Treatment of Coronary Artery Diseases Trial - Comparison of REDUCTION of PrasugrEl Dose & POLYmer TECHnology in ACS Patients (HOST REDUCE POLYTECH RCT Trial) Comparison of the Efficacy and Safety of Biostable Polymer DES (Promus PremierTM, Xience Alpine®, and Resolute Onyx®) With Biodegradable Polymer DES (Biomatrix®, Biomatrix Flex®, Nobori®, Ultimaster®,Synergy®, and Orsiro®)and Conventional Dose Prasugrel Therapy With Reduced Dose Prasugrel Therapy in Acute Coronary Syndrome Patients Treated With Percutaneous Coronary Intervention

Status: Active, no longer recruiting
Phase of Trial: Phase IV

Latest Information Update: 06 Jun 2022

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At a glance

  • Drugs Everolimus (Primary) ; Prasugrel
  • Indications Acute coronary syndromes
  • Focus Adverse reactions
  • Acronyms HOST-III-REDUCE-POLYTECH-RCT
  • Most Recent Events

    • 04 Apr 2022 Results of subgroup analysis assessing efficacy and safety of de-escalation of prasugrel therapy in patients with Diabetes Melitus presented at the 71st Annual Scientific Session of the American College of Cardiology
    • 18 Nov 2020 Results published in the Circulation
    • 02 Sep 2020 Primary endpoint (Antiplatelet arm : major adverse cardiovascular event (MACE), defined as a composite of all death, MI, stent thrombosis, repeat revascularization, CVA, and BARC class 2 bleeding) has been met according to the results published in the Lancet
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