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A Phase 3, Randomized, Double-blind Study Of Pf-05280586 Versus Rituximab For The First-line Treatment Of Patients With Cd20-positive, Low Tumor Burden, Follicular Lymphoma

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Trial Profile

A Phase 3, Randomized, Double-blind Study Of Pf-05280586 Versus Rituximab For The First-line Treatment Of Patients With Cd20-positive, Low Tumor Burden, Follicular Lymphoma

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 22 Dec 2021

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At a glance

  • Drugs Rituximab (Primary)
  • Indications Follicular lymphoma
  • Focus Registrational; Therapeutic Use
  • Acronyms REFLECTIONS
  • Sponsors Pfizer

    • Most Recent Events

    • 12 Jun 2021 Results of a retrospective analysis evaluated the impact of dosing/infusion patterns and certain baseline characteristics on infusion related reactions occurrence published in the BioDrugs
    • 31 May 2020 Results assessing if IRRs were correlated with infusion rates of the first dose of the RTX biosimilar PF-05280586 (RTX-PF) or reference RTX sourced from the EU (RTX-EU) presented at the 56th Annual Meeting of the American Society of Clinical Oncology
    • 02 Apr 2020 According to a Pfizer media release, European Commission (EC) has approved RUXIENCE (rituximab), a monoclonal antibody (mAb) and biosimilar to MabThera (rituximab), for the treatment of non-Hodgkins lymphoma (NHL), chronic lymphocytic leukemia (CLL), rheumatoid arthritis (RA), granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), and pemphigus vulgaris (PV).Based on the results of this trial

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